What is it about?
We cloned and sequenced Paramecium gene fragments encoding the following components participating in endosome formation, sorting and maturation of the proprotein precursors: dynamin 2, Rab7 and furin.
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Why is it important?
There is a proof that all these genes are expressed in this unicellular organism and share a considerable homology with their mammalian counterparts
Perspectives
We showed evolutionary conservancy of the endocytic and trafficking machinery in the unicellular eukaryote Paramecium.In Metazoa, endocytosis is a source of nutrients, hormones, growth factors, antibodies, lipoproteins and pathogenic substances.Endocytic pathway may be utilized in biology and medicine as a non-destructive delivery of macromolecules such as antibodies, enzymes and genes into living cells. On the other hand, disturbances in this pathway and/or its components may lead to severe human malfunctions.
Professor Elzbieta Wyroba
Nencki Institute of Experimental Biology
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This page is a summary of: Evolutionary conservancy of the endocytic and trafficking machinery in the unicellular eukaryote Paramecium, Biology of the Cell, March 2003, Wiley,
DOI: 10.1016/s0248-4900(03)00012-1.
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