1,4-Bis(arylsulfonyl)-1,2,3,4-tetrahydropyridines in synthesis. Regio- and stereoselective SN1 reactions

Jean-Claude Adelbrecht, Donald Craig, Serge Thorimbert
  • Tetrahedron Letters, November 2001, Elsevier
  • DOI: 10.1016/s0040-4039(01)01771-3

What is it about?

1,4-B is (4-tolylsulfonyl)-1,2,3,4-tetrahydropyridines undergo stereoselective S(N)1 reactions with soft carbon nucleophiles in the presence of Lewis acids. Subsequent dihydroxylation of the double bond followed by esterification enables the stereoselective preparation of substituted piperidines

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The following have contributed to this page: Professor Serge THORIMBERT