What is it about?
In general, propofol dose requirement and complications were lower when used with the diluted form in comparison with the undiluted form. The aim of this study was to determine the dose requirement and complication of diluted and undiluted propofol for deep sedation for endoscopic retrograde cholangiopancreatography (ERCP).
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Why is it important?
All endoscopies were completed successfully. Mean propofol doses per body weight and per body weight per hour in group D and U were 3.0 mg/kg, 6.2 mg/kg/hr and 4.7 mg/kg, 8.0 mg/kg/hr, respectively. The mean dose of propofol, expressed as total dose, dose/kg or dose/kg/hr and the recovery time in both groups was not significantly different. Sedation- related adverse events during and immediately after the procedure in group U (42.9%), were significantly higher than in group D (18.2%) (p=0.013).
Perspectives
Propofol requirement and recovery time in diluted and undiluted propofol groups was comparable. However, the complications in the diluted propofol group were significantly lower than in the undiluted propofol group.
Professor Somchai Amornyotin
Department of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University
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This page is a summary of: S1021 Dose Requirement and Complication of Diluted and Undiluted Propofol for Deep Sedation for Endoscopic Retrograde Cholangiopancreatography, Gastroenterology, May 2010, Elsevier,
DOI: 10.1016/s0016-5085(10)60743-3.
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