What is it about?
FXR by inducing UGT2B4 reduces intra cellular bile acids and hence detoxify bile acids but also controls its own activation by removing its ligands
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Why is it important?
FXR modulation could help to detoxify toxic bile
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This page is a summary of: FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity, Gastroenterology, June 2003, Elsevier,
DOI: 10.1016/s0016-5085(03)00388-3.
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