What is it about?
A 31-year-old man with mild hemophilia B developed a herniated disc treated with prednisolone for back pain. Surprisingly, hemostasis result tests performed before epidural infiltration were a normal activated partial thrombin time at 36.1 s. (normal range 27.9-37.7 s.) and factor IX (FIX) level 76% (normal range>70%), 13 days after prednisolone introduction.
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Why is it important?
This new case of FIX normalization showed the necessity to have a perfect knowledge of patient’s treatment to avoid misdiagnosis and a temporary normal hemostasis permit to perform epidural infiltration without replacement therapy.
Perspectives
A study in Hemophilia B could be performed to evaluate FIX increase under prednisolone treatment
Paul Billoir
Rouen University Hospital Vascular Hemostasis Unit
Read the Original
This page is a summary of: Prednisolone treatment induced temporary Factor IX normalization in mild hemophilia B who required an epidural infiltration: a case report, Transfusion and Apheresis Science, June 2019, Elsevier,
DOI: 10.1016/j.transci.2019.05.009.
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