Core-shell particles lead the way to renewing high-performance liquid chromatography

What is it about?

we present the latest highlights and trends in the use of core-shell particles as stationary phases in columns for liquid chromatography (LC). These highly homogeneous particles have a diame- ter of 1.3–5 μm with a solid silica core and a porous surface that make their performance excellent compared to fully-porous particles. Use of these columns has been growing exponentially since their first large- scale manufacture in 2006, and they are an emerging trend in the analysis of biological, toxicological and pharmaceutically interesting compounds.

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Why is it important?

We review the main theoretical aspects responsible for their surprisingly good chromatographic behavior and analytical features. We also summarize state-of- the-art analytical applications taking advantage of this column technology that is leading the current revolution in LC.