EXPERIMENTAL LESIONS PRODUCED BY THE VENOM OF PHONEUTRIA NIGRIVENTER SPIDERS

What is it about?

We studied the toxicity of samples of venom of Phoneutria spiders from the provinces of Misiones where severe envenomation and deaths by Phoneutira were recorded and from the province of Jujuy, where no deaths were recorded and severe envenomations are not frequent. The lethal potency in mice and Guinea pigs and the histopathological alterations produced by both venoms as well as the neutralization by the commonly used therapeutic antivenom produced by the Butantan Institute in Brazil and by an experimental antivenom developed with venom of P. nigriventer from Misiones were assayed. No differences in the toxic potency were found between the venoms of spiders from both regions

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Why is it important?

This is the first study on the toxicity and the histopathological alterations produced by the venom of P. nigriventer from different regions of Argentina as well as on the experimental usefulness of the antivenom made with Misiones spider venom or made with venom from Brazilian Phoneutria on the venom of P. nigriventer