What is it about?
Drs Maus and Nauen of Bayer CropScience contested the irreversible nature of receptor binding by imidacloprid in insects. However, they did not retract previous assertions made by their colleagues Abbink (1991), Mencke and Hansen (1999). The latter paper [Parasitol Res (1999) 85: 625-637] clearly states that “the irreversible blocking [by imidacloprid] of the nACh receptors leads to a lethal hyperactivity of the nerves and muscles of the insect.”
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Why is it important?
It demonstrates that Bayer CropScience ditched a mechanism of action they had previously described in great detail, and confirmed by Tennekes, to prevent unfavorable regulatory action.
Perspectives
The U turn made by Bayer CropScience was clearly a result of the commercial interests at stake
Dr Henk A. Tennekes
Experimental Toxicology Services (ETS) Nederland BV
Read the Original
This page is a summary of: The significance of the Druckrey–Küpfmüller equation for risk assessment—The toxicity of neonicotinoid insecticides to arthropods is reinforced by exposure time: Responding to a Letter to the Editor by Drs. C. Maus and R. Nauen of Bayer CropScience AG, Toxicology, February 2011, Elsevier,
DOI: 10.1016/j.tox.2010.11.015.
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