What is it about?
The new pyrimidine-pyrrole scaffolds (7a–7m) with substituted 1,2,3-traizole moiety were synthesized in good to mild yields and subjected for anti-cancer activity against melanoma and breast cancer cell lines using MTT assay.
Featured Image
Why is it important?
The compounds 7f and 7m exhibited highest anti-cancer activity against both the tested cell lines in in vitro assay. The molecular docking analysis provided the insights of binding orientation of pyrimidine-pyrrole nucleus of current ligands and their crucial interactions with Cys797 and other residues of the EGFR tyrosine kinase active site.
Perspectives
The interactions of triazole and its various substituted groups with EGFR tyrosine kinase have been discussed
Prof Ratnakaram Venkata Nadh
GITAM University
Read the Original
This page is a summary of: Design, synthesis and anti-tumour activity of new pyrimidine-pyrrole appended triazoles, Toxicology in Vitro, October 2019, Elsevier,
DOI: 10.1016/j.tiv.2019.05.009.
You can read the full text:
Contributors
The following have contributed to this page
