Lower dosage of rt-PA in the treatment of acute pulmonary embolism

What is it about?

This meta-analysis showed that low dose rt-PA was superior to standard dose rt-PA in preventingmajor bleeding events and remained similar efficacy. In addition, compared with heparin, low dose rt-PA didn’t increase the risk of bleeding for eligible PE patients.

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Why is it important?

Although the indications of thrombolytic therapy for acute PE are controversial. Thrombolysis may be considered for these patients after they are judged to have clinical evidence of adverse prognosis and low risk of bleeding complications. In terms of reduction of bleeding events and balance between the benefit and risk ratio, lower doses of rt-PA could be considered for PE patients.