What is it about?

Enantioselective molecular recognition of -amino acid derivatives by two chiral uranyl-salen hosts was investigated by NMR data. The receptors differ for the presence of two tert-butyl groups in the salen backbone. The uranyl hosts have shown high binding constant values and excellent enantioselectivities for the selected guests (up to 100 for the tryptophan derivative).

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Why is it important?

chiral recognition of amino acids allow to an easy detection of several diseases

Perspectives

this study pave the way for a better understanding of the intrinsic mechanism of enantiomeric recognition using this class of artificial hosts

Dr Giuseppe Trusso Sfrazzetto
University of Catania

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This page is a summary of: Enantiomeric recognition of α-amino acid derivatives by chiral uranyl–salen receptors, Tetrahedron Letters, May 2015, Elsevier,
DOI: 10.1016/j.tetlet.2015.04.092.
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