Proton pump inhibitors induce changes in colonocyte gene expression that may affect Clostridium difficile infection

What is it about?

Proton pump inhibitors seem to promote Clostridium difficile infection (CDI). The aim of this study was to investigate the effect of omeprazole on genome-wide gene expression in a human colonic cell line.

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Why is it important?

Omeprazole treatment decreases the expression of genes that have important functions in colonocyte integrity. Such impairment in colonocyte function may promote CDI.