What is it about?
We sequenced 27 genes linked to plasma levels of coagulation factor VIII and von willebrand factor (VWF) because factor VIII level is a strong risk factor for venous thromboembolism. A three variant risk score in the F8, ABO and VWF genes is strongly linked to venous thromboembolism. The three variant risk score is of similar strength as factor V Leiden and the prothrombin G20210A mutation..
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Why is it important?
A common three variant risk score is of similar strength as known inherited thrombophilias. The variants are common in all ethnic populations in gnomAD.
Perspectives
A common three variant risk score is of similar strength as known inherited thrombophilias. The three variants are common in all ethnic populations in gnomAD. The score is the strongest genetic risk factor for venous thromboembolism since the discovery of Factor V Leiden and the prothrombin G20210A mutation.
Professor, MD, PhD Bengt Zöller
Lunds Universitet
Read the Original
This page is a summary of: Thrombotic risk determined by ABO, F8 and VWF variants in a population-based cohort study, Research and Practice in Thrombosis and Haemostasis, April 2025, Elsevier,
DOI: 10.1016/j.rpth.2025.102875.
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