Influence of epithelium on beta-adrenoceptor desensitization of guinea pig tracheal smooth muscle

What is it about?

The effect of tissue incubation with a alpha2-agonist of denuded and intact epithelium trachea on the responsiveness to isoprenaline and alpha-receptor blocked by propranolol (CR-1) was examined in this study. We examined the effect of epithelium removal on the alpha-adrenoceptor desensitization resulting from incubation of guinea pig trachea in the alpha-adrenergic agonist isoprenaline (10 mM).

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Why is it important?

These results indicate decrease in both tracheal response to alpha-agonist (tolerance) and CR-1 (due to incubation of tissues with isoprenaline), which were greater in denuded epithelium groups.