What is it about?
GFAP is a protein of astrocytes susceptible to oxidation by different agents. The presence of mutations described in Alexander disease patients alters the oxidation pattern by diverse agents in vitro.
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Why is it important?
The presence of new residues susceptible of oxidative modifications due to mutations detected in Alexander disease impacts the GFAP filament network differentially according to the substitution introduced. Hence, the impact on the network itself, but also in the protein interactions involving GFAP will be affected.
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This page is a summary of: Alexander disease mutations differentially sensitize glial fibrillary acidic protein (GFAP) to posttranslational modifications and network disruption by oxidants, Redox Biology, May 2026, Elsevier,
DOI: 10.1016/j.redox.2026.104103.
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