What is it about?
This study explains the synthesis, nature and anticancer properties of mono- and dinuclear Ni(II) and Co(II) complexes of a Schiff base ligand (LA) derived from ortho-vanillin and ortho-phenylenediamine. Physicochemical and spectral properties were used to identify the characteristics of the ligand complexes while X-ray crystallography were used for mononuclear nickel(II), Ni(LA). The anticancer activity of these compounds specifically for human colorectal cancer HCT116 has been identified as well.
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Why is it important?
Schiff bases and their complexes have been gaining attention mainly due to their unique structures and electronic properties which could be manipulated to enhance significant bioactivity. The differences in the characteristics of LA and its mononuclear and dinuclear Ni(II) and Co(II) complexes as in structural architecture and electronic properties have been studied. It is highlighted that the anticancer properties of Ni(II) complexes prevails that of Co(II) complexes.
Perspectives
Cancer is one of the most fatal diseases of the 21st century. A wide range of cytotoxic drugs with different mechanisms of action are used to treat this disease, either alone or in combination. The main drawback of these drugs is the side effects that are caused mainly by their indiscriminate action against both cancerous and healthy cells. There is an urgent need to find new and improved anticancer agents to fight this disease. This paper describes the synthesis, structure elucidation and anticancer screening of a Schiff base ligand together with its mononuclear and binuclear nickel(II) and cobalt(II) complexes. The ligand and complexes were characterized via their physicochemical and spectral properties, and X-ray crystallography for Ni(LA).
Prof Dr Hadariah Bahron
Universiti Teknologi MARA
Read the Original
This page is a summary of: Synthesis, characterization and anticancer activity of mono- and dinuclear Ni(II) and Co(II) complexes of a Schiff base derived from o-vanillin, Polyhedron, March 2019, Elsevier,
DOI: 10.1016/j.poly.2018.12.055.
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