What is it about?
Experimental studies have demonstrated that free radicals play a major role on neuronal injury during ischemia/reperfusion (I/R) in rats. Erdosteine is a thioderivative endowed with mucokinetic, mucolytic and free-radical-scavenging properties. The aim of the present study was to investigate the effect of erdosteine treatment against short-term global brain ischemia/reperfusion injury in rats.
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Why is it important?
By treating the rats with erdosteine, the depletion of endogenous antioxidant enzymes (SOD, CAT, GSH-Px) and increase of TBARS and NO levels were prevented. This study, therefore, suggests that erdosteine reduces parameters of oxidative stress is well supported by the data.
Perspectives
In conclusion, the present report represents the first evidence that erdosteine reduces oxidative stress caused by I/R, so that, it may reduce free radical based damages, such as neuronal death. Further studies are needed to clarify if erdosteine has a direct neuroprotective effect on brain damage caused by I/R.
Dr Sedat Bilgiç
Adiyaman Universitesi
Read the Original
This page is a summary of: The protective effect of erdosteine on short-term global brain ischemia/reperfusion injury in rats, Progress in Neuro-Psychopharmacology and Biological Psychiatry, February 2009, Elsevier,
DOI: 10.1016/j.pnpbp.2008.09.024.
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