Palmitoylethanolamide (PEA)—‘Promiscuous’ anti-inflammatory and analgesic molecule at the interface between nutrition and pharma

Jan M. Keppel Hesselink, David J. Kopsky, Renger F. Witkamp
  • PharmaNutrition, January 2014, Elsevier
  • DOI: 10.1016/j.phanu.2013.11.127

What is it about?

Palmitoylethanolamide is a new kid on the block in autacoid medicine, and widely available as a food supplement. In this article we describe the growing insight in the relevance of this natural compound for the treatment of chronic pain and its interface between nutrition and food. Such molecules can be found in all living beings (plants and animals) and need special care, as new therapeutic inroads making use of restorative pathways in our body.

Why is it important?

Using autacoid lipids such as PEA helps to treat patients in absence of side effect, activating body-own restorative pathways.


jan keppel hesselink
Institute Neuropathic Pain

I work since 2010 with PEA in the clinic and see many very relevant positive responses, colleagues should more often think about using PEA for chronic disorders, especially since it has a steroid and opiate sparing effect! As a very useful adjunct to chronic pain and chronic inflammation it needs more exposure!

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The following have contributed to this page: jan keppel hesselink, Mr David Jos Kopsky, and Professor Renger Witkamp