What is it about?
A "False Premise" is an inaccurate proposition that forms the base of an argument. As the proposition is incorrect, the conclusion of the argument will invariably be wrong. However, the arguments themselves may be sound, consistent and logical, and thus the conclusion will appear correct superficially. But a careful dissection into the basis of the arguments will identify the erroneous nature. The medical condition of APDE fits well into a False Premise.
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Why is it important?
Adding case reports into the category of Acquired Platelet Dysfunction with Eosinophilia (APDE) only reinforces the arguments and distracts further researches and understanding of the true nature and identity of this underlying childhood illness. More then 90% of the cases reported so far in the medical literature come from Thailand. However, none of the publications from Thailand gives a clear definition how the disease is diagnosed in Thailand. If you read carefully into their major series of patients, you can see the contradictions among the arguments inside their papers.
Perspectives
If you come across a similar case, document carefully the clinical and laboratory features. Keep your mind open and you will soon see the next case. Explore other diagnostic arguments such as advanced platelet function tests, electron microscopy, and genomics. I believe this is the way forward to understand this illness that I call Idiopathic Purpura with Gray Platelets.
Dr Anselm C Lee
Mount Elizabeth Hospital
Read the Original
This page is a summary of: Acquired platelet dysfunction with eosinophilia: A false premise, Pediatrics & Neonatology, August 2020, Elsevier,
DOI: 10.1016/j.pedneo.2020.08.001.
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