What is it about?

Kidney Impairment is assoxciated with α-Synucleinopathy (e.g., Parkinson's Disease and Lewy Body dementia). Potential mechanisms underlying this association are discussed, as well as potential use of AChEIs to mitigate symptom progression.

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Why is it important?

The synthesis of data on the paper suggest that the use of AChEIs can slow and/or mitigate the deverlopment of α-Synucleinopathy in the CNS.

Perspectives

This paper suggests potentail mechanisms for α-Synucleinopathy and its relationship to renal functioning, as well as potential methods for symptom mitigation.

Dr. Charles M Lepkowsky

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This page is a summary of: Kidney Impairment and α-Synucleinopathy: Implications for Assessment and Treatment, The American Journal of Geriatric Psychiatry Open Science Education and Practice, December 2025, Elsevier,
DOI: 10.1016/j.osep.2025.10.001.
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