What is it about?
The ratio of PAI-1 and tPA regulates ECM production
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Why is it important?
The ratio of PAI-1 and tPA is an important regulator of ECM production. The radio of 1:1 is between these two need to be maintained for normal ECM. Any increase of decrease in the ratio can promote fibrosis
Perspectives
Different ratio of PAI-1 and tPA should be correlated with different stages of Oral Submucous Fibrosis for disease insights
Professor Mohit Sharma
SGT Dental College Hospital & Research Institute
Read the Original
This page is a summary of: Unfavourable stoichiometry of PAI-1 and tPA foments OSMF, Oral Oncology, July 2016, Elsevier,
DOI: 10.1016/j.oraloncology.2016.05.001.
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