Wound healing synergy in Wistar albino rats via green synthesized nanoparticles .

What is it about?

Raise of antimicrobial resistance and lack of development in novel antibiotics leads to complications in infection control for wound healing. In perspective to search for best alternatives, antibacterial activity of nanomaterials has shown promising strategy, however concentration dependent toxicity became challenge thereof. In this context, green synthesis protocols of nano materials provide benefits of biocompatibility due to presence of bioactive compounds and also economical with proven efficiency. Further nano-antibiotic combinations may enhance antibacterial efficacy by synergetic action and allows to reduce the dosage of both agents. In the current work, nano-antibiotic gels are prepared using green synthesized nanoparticles (Ag & ZnO NPs) with the combination of antibiotic neomycin and also assessed in-vivo wound healing activity on Wistar albino rats. From the results of the tested formulations, combinational formulations exhibited enhanced and speedier wound contraction (92–96%) with prominent synergetic action when compared with neomycin alone (84%) or nanoparticles alone (82–86%) in a 14-day study. These results demonstrated that green-nano-antibiotic combinational formulations provides prominent avenue to combat the multi drug resistant bacteria without toxicity issue.

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Why is it important?

Wound healing is a series of four different phases i.e; hemostasis, inflammation, proliferation and maturation. Poor wound healing is mostly associated with bacterial infections especially multidrug resistance bacteria (MDR), which leads to chronic wounds resulting in life risk complications . The reports of World Health Organization (WHO), the mortality rate due to MDR infections are more than all types of cancer together [3,4]. Therefore, treatment of wounds with existing conventional antibiotics became major challenge for clinicians due to lack of novel antimicrobial molecules. There is potential gap in rise in antibacterial resistance and development of novel antibiotics [5,6]. In this context, as a novel strategy to combat MDR much attention has been paid in recent past towards nanomaterial-based antimicrobials.

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