What is it about?
Schizophrenia is a chronic neuropsychiatric disorder with a strong genetic component. Among the genes implicated, the brain-derived neurotrophic factor (BDNF) gene, particularly the functional polymorphism rs6265 (Val66Met), has garnered considerable attention due to its critical role in neurodevelopment, synaptic plasticity, and cognitive functioning. This study combines prospective case-control data with an updated meta-analysis to assess the association between the BDNF rs6265 polymorphism and susceptibility to schizophrenia. The pooled analysis across diverse populations and genetic models reveals a statistically significant association between the Met allele and increased risk of schizophrenia. These findings underscore the importance of BDNF as a potential genetic biomarker for schizophrenia, supporting its integration into future diagnostic and risk assessment strategies.
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Why is it important?
Confirms BDNF rs6265 (Val66Met) polymorphism as a significant genetic risk factor for schizophrenia. Supports the use of BDNF variants in genetic screening and early risk prediction for schizophrenia. Opens avenues for targeted interventions aimed at modulating BDNF signaling in susceptible individuals.
Perspectives
The study contributes to the growing body of evidence linking the BDNF rs6265 polymorphism with schizophrenia, highlighting a critical genetic factor in the etiology of this complex disorder. The Met allele’s association with reduced activity-dependent secretion of BDNF and impaired neuroplasticity may underlie the cognitive and structural brain abnormalities observed in schizophrenia. By integrating both prospective data and comprehensive meta-analysis, the findings provide a more robust understanding of the genetic risk landscape. This supports the implementation of gene-based screening tools and early intervention strategies for individuals at high risk. Furthermore, the study encourages exploration of BDNF-targeted therapeutic approaches, which could lead to more personalized and effective treatments for schizophrenia.
Dr.Ramakrishnan Veerabathiran
Chettinad Health City
Read the Original
This page is a summary of: Genetic predisposition of BDNF (rs6265) gene is susceptible to Schizophrenia: A prospective study and updated meta-analysis, Neurología (English Edition), May 2024, Elsevier,
DOI: 10.1016/j.nrleng.2024.03.001.
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