What is it about?
The BDNF (Brain-Derived Neurotrophic Factor) gene, particularly the rs6265 (Val66Met) polymorphism, has been implicated in neurodevelopmental processes and synaptic plasticity—both of which are crucial in the pathophysiology of schizophrenia. This study combines a prospective case-control approach with an updated meta-analysis to evaluate the association between the rs6265 variant and schizophrenia susceptibility. The research aims to clarify inconsistent findings in previous literature by incorporating new data, larger sample sizes, and genetic models (allelic, dominant, recessive). Findings suggest that individuals carrying the Met allele may have altered BDNF expression, potentially increasing vulnerability to schizophrenia through impaired neuroplasticity and neuronal signaling.
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Why is it important?
Understanding the genetic predisposition conferred by BDNF rs6265 is crucial for unraveling the complex etiology of schizophrenia. This knowledge can aid in identifying at-risk individuals before symptom onset, enhancing early intervention efforts. Moreover, it supports the development of personalized treatment strategies targeting neurotrophic pathways and underscores the importance of including genetic data in psychiatric research and clinical decision-making.
Perspectives
BDNF rs6265 affects brain structure, function, and synaptic regulation, offering mechanistic understanding of schizophrenia at the molecular level. The Val66Met variant may serve as a genetic biomarker for early identification of schizophrenia risk in genetically predisposed individuals. Combining meta-analytic and prospective data strengthens evidence, supporting the integration of genetic screening into psychiatric assessment protocols.
Dr.Ramakrishnan Veerabathiran
Chettinad Health City
Read the Original
This page is a summary of: Genetic predisposition of BDNF (rs6265) gene is susceptible to Schizophrenia: A prospective study and updated meta-analysis, Neurología, May 2024, Elsevier,
DOI: 10.1016/j.nrl.2021.10.006.
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