What is it about?
GK rats become hyperphagic and hyperglycaemic in weaning stage. Feeding related peptides, especially POMC, mRNA expressions and POMC [Ca2+]i response to hyperglycaemia decreased in accurate nucleus of just weaned GK rats.
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Why is it important?
Kind of positive feedback relations between hyperglycaemia and hyperphagia may be present in type 2 diabetic animal model.
Perspectives
I hope this article may suggest some hints on dietary and glycaemic controls in type 2 diabetic patients.
Dr Akihiko Ando
Jichi Ika Daigaku
Read the Original
This page is a summary of: Weaning stage hyperglycemia induces glucose-insensitivity in arcuate POMC neurons and hyperphagia in type 2 diabetic GK rats, Neuropeptides, April 2018, Elsevier,
DOI: 10.1016/j.npep.2018.02.001.
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