LY293558 prevents soman-induced pathophysiological alterations in the basolateral amygdala and the development of anxiety

What is it about?

In this study, we find that administering a GluK5 antagonist within 20 minutes of a nerve agent exposure will prevent long term deficits in synaptic plasticity, and will prevent the associated increases in anxiety-like behavior.

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Why is it important?

This work is important because it provides a novel treatment option to prevent long term deficits after a nerve agent exposure.