What is it about?
Highlights •Moderate-stage AD patients have low levels of six cytokines in the plasma. Six significantly reduced cytokines are highly interacting proteins, MMP-9, RANTES, MCP-1, MIP-1α, MIP-1β, and VEGF-A. They are included in the IL-18 signaling pathway.The severity of AD increases, the decrease in cytokine levels is associated with a decreased immune response.
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Why is it important?
Alterations of some plasma cytokines may play role in pathophysiology of Alzheimer's Disease.
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This page is a summary of: Decreased levels of cytokines implicate altered immune response in plasma of moderate-stage Alzheimer’s disease patients, Neuroscience Letters, August 2022, Elsevier,
DOI: 10.1016/j.neulet.2022.136799.
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