What is it about?
NOS-2 is a protein that initiates the production of nitric oxide; in the brain, it is related to inflammatory states. We have shown for the first time that, in zebrafish, alcohol withdrawal increases nitric oxide in the brain, and that blocking NOS-2 with a drug called aminoguanidine stops both this neurochemical effect and the behavioral consequences of withdrawal.
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Why is it important?
Alcohol withdrawal syndrome is a debilitating condition that is highly prevalent due to the high use of alcohol in our culture. Describing mechanisms associated with this condition can help promote treatment and relief for people suffering from alcohol withdrawal syndrome.
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This page is a summary of: NOS-2 participates in the behavioral effects of ethanol withdrawal in zebrafish, Neuroscience Letters, May 2020, Elsevier,
DOI: 10.1016/j.neulet.2020.134952.
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