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Our group developed a mouse model to track the production of dopaminergic neurons, the neurons responsible for the motor features of Parkinson's disease, by stem cells. We found that these important neurons are slowly replenished in adult mice. This may overturn the long-held belief that adult mammals possess the same dopaminergic neurons throughout life thereby implying that their loss is irreversible. This study provides compelling evidence for replenishment of dopaminergic neurons as an ongoing natural process in adults that could be targeted for Parkinson's disease therapy.
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This page is a summary of: Nestin-positive/SOX2−negative cells mediate adult neurogenesis of nigral dopaminergic neurons in mice, Neuroscience Letters, February 2016, Elsevier,
DOI: 10.1016/j.neulet.2016.01.019.
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