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The main findings of this paper were: 1) The polyunsaturated essential fatty acid Arachidonic Acid (AA) induced mitochondrial apoptosis of human brain endothelial cells (HBECs). 2) AA stimulated stress signalling via phosphorylated p38-MAPK/MAPKAP-2/Hsp27 and intracellular calcium release. 3) The involvement of AA in p38-MAPK, Hsp27 and IP3 signalling was confirmed using selective inhibitors and antagonists. These findings support a previously unrecognized signaling cooperation between p38-MAPK/MAPKAP-2/Hsp27 and intracellular calcium release in AA-induced HBEC apoptosis and suggest its relevance to neurological disorders associated with vascular inflammation.

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This page is a summary of: Arachidonic acid induces brain endothelial cell apoptosis via p38-MAPK and intracellular calcium signaling, Microvascular Research, March 2015, Elsevier,
DOI: 10.1016/j.mvr.2014.04.011.
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