Synthesis, crystal structure, catalytic and anti- Trypanosoma cruzi activity of a new chromium(III) complex containing bis(3,5-dimethylpyrazol-1-yl)methane

John Hurtado, Laura Ibarra, David Yepes, Paola García-Huertas, Mario A. Macías, Omar Triana-Chavez, Edgar Nagles, Leopoldo Suescun, Alvaro Muñoz-Castro
  • Journal of Molecular Structure, October 2017, Elsevier
  • DOI: 10.1016/j.molstruc.2017.06.014

A new chromium(III) complex with anti-Trypanosoma cruzi activity

What is it about?

The reaction of CrCl36H2O with the ligand bis(3,5-dimethylpyrazol-1-yl)methane (L) yielded the cationic complex [(Cr(L)(H2O)2Cl2]+, which crystallized as the chloride trihydrate [(Cr(L)(H2O)2Cl2]Cl*3H2O. The chromium complex was characterized by elemental analysis, electrical conductivity, Infrared and Ultraviolet/ Visible spectroscopy. The crystal structure determination using single-crystal X-ray diffraction showed a chromium center in a distorted octahedral coordination sphere. In the crystal, the packing was directed by O...H-(O,Cl) hydrogen bonds and weak C...H-O interactions to build a monoclinic P21/c supramolecular structure. The complex showed excellent properties as an initiator for the ring opening polymerization of є-caprolactone (CL) under solvent-free conditions.

Why is it important?

The complex has a high activity against this parasite with a minimum inhibitory concentration 50 (MIC50) of 1.08 mg/mL. Interestingly, this compound showed little effect on erythrocytes, indicating that it is not cytotoxic. These results provide interesting contributions to the design of metal complexes by using simple and accessible ligands with activity against T. cruzi and with potential applications in the polymerization of CL.

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The following have contributed to this page: Dr Mario Alberto Macías