Why lipostatic set point systems are unlikely to evolve

John R. Speakman
  • Molecular Metabolism, January 2018, Elsevier
  • DOI: 10.1016/j.molmet.2017.10.007

Regulation of body weight theories

What is it about?

The most widely believed idea for the evolution of body weight regulation is the lipostatic set point model. In this paper I use mathematical modelling to show such systems are unlikely to evolve by the envisaged mechanisms.

Why is it important?

Most of the studies of body weight control are interpreted by this model - yet it is unlikely to be correct.

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The following have contributed to this page: Professor John Speakman