Treatment resistance in major depression is correlated with increased plasma levels of neurofilament light protein reflecting axonal damage

Susanne Spanier, Hannah M. Kilian, Dora M. Meyer, Thomas E. Schlaepfer
  • Medical Hypotheses, June 2019, Elsevier
  • DOI: 10.1016/j.mehy.2019.03.022

Brain Changes in Treatment Resistant Depression

What is it about?

The feature of treatment resistance in Major depression might be explained by axonal damage.

Why is it important?

If there are indeed increased plasma levels of neurofilament light protein in treatment resistant depression, this might be a useful biomarker. We will test this hypothesis in an ongoing study of Deep Brain Stimulation for Treatment Resistant Depression.

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http://dx.doi.org/10.1016/j.mehy.2019.03.022

The following have contributed to this page: Thomas E. Schlaepfer