What is it about?
The feature of treatment resistance in Major depression might be explained by axonal damage.
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Why is it important?
If there are indeed increased plasma levels of neurofilament light protein in treatment resistant depression, this might be a useful biomarker. We will test this hypothesis in an ongoing study of Deep Brain Stimulation for Treatment Resistant Depression.
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This page is a summary of: Treatment resistance in major depression is correlated with increased plasma levels of neurofilament light protein reflecting axonal damage, Medical Hypotheses, June 2019, Elsevier,
DOI: 10.1016/j.mehy.2019.03.022.
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