What is it about?
1. Brain uses GLUT 1 and 3 membrane transport to get Glucose in to neurones 2. Functional or structural deficits can lead to brain cell deficits in energy production 3. Frontal lobes are particularly sensitive to Glucose uptake 4. Hypofrontality is a key feature of schizophrenia
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Why is it important?
1. The Dopamine hypothesis is increasingly considered to be a phenomena secondary to hypofrontality 2. Raises the prospect of using ketones to provide brain nutrition in schizophrenia
Perspectives
Emma (the first author) was one of my medical students; introduced me to the complexities of GLUT transporters and its relevance to brain energetics.
Dr Prasanna Nemichandra de silva
NHS Providers
Read the Original
This page is a summary of: Impaired neuronal glucose uptake in pathogenesis of schizophrenia – Can GLUT 1 and GLUT 3 deficits explain imaging, post-mortem and pharmacological findings?, Medical Hypotheses, January 2005, Elsevier,
DOI: 10.1016/j.mehy.2005.06.022.
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