Overexpression of Steroid Sulfatase Alleviates Cholestasis

What is it about?

We have shown that overexpression of an enzyme-steroid sulfatase-in the liver promoted bile acid elimination and alleviated bile acid-induced cholestasis in mice.

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Why is it important?

We uncovered a novel regulator in the protection of bile acid-induced cholestasis and liver toxicity. We also have provided evidence that overexpression of an endobiotic metabolism enzyme may activate a nuclear receptor by regulating the homeostasis of its endogenous ligands.