What is it about?
The present study has shown that treatment with RUV significantly protects against reproductive damage in male diabetic rats in a dose-dependent manner. The involved mechanisms include inhibition of oxidative stress, inflammatory and apoptotic-related pathways, such as reduction of testicular MOP activity and suppression of iNOS, NF-κB-p65 and caspase-3 expressions.
Featured Image
Why is it important?
we suggest that inhibition of NF-κB and caspase-3 pathways by RUV may be involved in the testicular protective effects of RUV against diabetes through suppression of iNOS induction.
Perspectives
The results of the present study indicate that RUV supplementation reduces reproductive damage in STZ-induced diabetic rats in a dosedependent manner. The protective effect of RUV possibly involves the reduction of oxidative and inflammatory status, as well as, cell death via down-regulation of NF-κB, iNOS and caspase-3 expressions
Dr Alaaeldin A Hamza
National Organization for Drug Control and Research
Read the Original
This page is a summary of: Rosuvastatin ameliorates diabetes-induced reproductive damage via suppression of oxidative stress, inflammatory and apoptotic pathways in male rats, Life Sciences, November 2015, Elsevier,
DOI: 10.1016/j.lfs.2015.09.015.
You can read the full text:
Contributors
The following have contributed to this page
