A Model for Manganese interaction with Deinococcus radiodurans proteome network involved in ROS response and defense

M. Peana, C.T. Chasapis, G. Simula, S. Medici, M.A. Zoroddu
  • Journal of Trace Elements in Medicine and Biology, February 2018, Elsevier
  • DOI: 10.1016/j.jtemb.2018.02.001

Mn(II) interaction with proteins responsible for ROS response and defense in DR

What is it about?

Here a bioinformatic approaches is used to find the manganese-proteins that play a key role in radioprotection

Why is it important?

The application of new bioinformatic approaches to find the manganese-proteome and the Protein-protein interaction network

Perspectives

Dr Massimiliano F PEANA
Universita degli Studi di Sassari

The enhancement of the knowledge about the impact of Mn-binding proteins in DR ability to protect DNA from various damaging agents such as ionizing radiation, UV radiation and oxidative stress

Giancarlo Simula

In this study we have investigated the Mn proteome of Deinococcus radiodurans in order to elucidate the molecular mechanism of its extreme radioresistance. Furthermore, the interactome of Mn binding proteins has been unveiled. We have found evidence of the important role of Manganese in ROS scavenging and protein protection, which are key elements in the antioxidant mechanism of Dr.

Read Publication

http://dx.doi.org/10.1016/j.jtemb.2018.02.001

The following have contributed to this page: Dr Massimiliano F PEANA and Giancarlo Simula