Structural and evolutionary analysis of the co-activator binding domain in vertebrate progesterone receptors

What is it about?

This paper provides information about the interaction of the progesterone receptor with a key protein that increases the response to progesterone, a key reproductive steroid in women. Interestingly, progesterone has been found to have diverse actions in the brain in women and men.

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Why is it important?

The structure of the progesterone receptor with a coactivator has not been solved. Thus, this paper provides new information about the interaction between the progesterone receptor and a coactivator, which can be used to develop drugs for treating progesterone-responsive diseases.