What is it about?
Two new copper-based compounds were tested on breast cancer cells and showed stronger cell-killing effects than cisplatin while being less toxic to healthy cells. They induced stress, DNA damage, and programmed cell death via distinct molecular pathways.
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Why is it important?
Two new copper-based compounds killed breast cancer cells more effectively than cisplatin while sparing healthy cells. Uniquely, they triggered cancer cell death by reprogramming multiple energy, survival, and stress pathways in a distinct mechanism from cisplatin.
Perspectives
From a study perspective, this work shows that carefully designed copper-based compounds can selectively kill breast cancer cells more effectively than cisplatin by disrupting multiple survival pathways and triggering programmed cell death through a distinct, potentially safer mechanism.
Dr Zeinab Ghasemishahrestani
University of Cape Town
Read the Original
This page is a summary of: Dinuclear Cu2+-complexes disrupt cellular pathways and rewire the breast cancer proteome, Journal of Proteomics, January 2026, Elsevier,
DOI: 10.1016/j.jprot.2025.105570.
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