What is it about?

The present research described the in-depth study on solid state properties viz. physicochemical and thermal properties of magnesium gluconate using sophisticated analytical techniques like Powder X-ray diffraction (PXRD), particle size analysis (PSA), Fourier transform infrared (FT-IR) spectrometry, ultraviolet–visible (UV–Vis) spectroscopy, thermogravimetric analysis (TGA)/differential thermogravimetric analysis (DTG), and differential scanning calorimetry (DSC).

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Why is it important?

The present study successfully explored the physicochemical and thermal properties of a classical pharmaceutical/nutraceutical compound like magnesium gluconate in details using PXRD, PSA, FT-IR, UV–Vis, TGA, DTG and DSC techniques. In summary, magnesium gluconate was found to be crystalline in nature having crystallite size from 14.10 to 47.35 nm, maximum absorbance peak at 198.0 nm, and thermally stable up to around 165 °C with a melting temperature at 169.90 °C having enthalpy of fusion of 308.7 J/g. The acquired data are very useful in identifying and characterizing magnesium gluconate from its various polymorphs. Therefore, pharmaceutical and nutraceutical industries might require these pieces of information for the identification, characterization and qualitative analysis of magnesium gluconate for preformulation studies and also for developing magnesium gluconate-based novel formulation. This study might enhance the readers’ interest in knowing more about the solid state properties of organometallic pharmaceutical solids like magnesium gluconate.

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This page is a summary of: In-depth investigation on physicochemical and thermal properties of magnesium (II) gluconate using spectroscopic and thermoanalytical techniques, Journal of Pharmaceutical Analysis, October 2017, Elsevier,
DOI: 10.1016/j.jpha.2017.03.006.
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