What is it about?
The use of animal models of aortic stenosis (AS) remains essential to further elucidate its pathophysiology and to evaluate new therapeutic strategies. The waved-2 mouse AS model has been proposed; data have indicated that while aortic regurgitation (AR) is effectively induced, development of AS is rare. We aimed to evaluate the effect of high-fat diet (HFD) and vitamin D3 supplementation in this model
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Perspectives
These results suggest that HFD and vitamin D3 supplementation have no effect in the waved-2 mice model. This model essentially mimics AR and rarely AS. Further studies are needed to find a reliable animal model of AS.
Paul Billoir
Rouen University Hospital Vascular Hemostasis Unit
Read the Original
This page is a summary of: Impact of high-fat diet and vitamin D3 supplementation on aortic stenosis establishment in waved-2 epidermal growth factor receptor mutant mice‘, Journal of Integrative Medicine, January 2019, Elsevier,
DOI: 10.1016/j.joim.2019.01.010.
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