What is it about?
Transcription factor 7-like 2 (TCF7L2)-rs7903146 polymorphism is associated with increased risk of type 2 diabetes. The response of insulin and insulin resistance to artichoke leaf extract (ALE) may be affected by TCF7L2-rs7903146 polymorphism. This study was designed to examine the effects of ALE supplementation on metabolic parameters of the TCF7L2-rs7903146 polymorphism in patients with metabolic syndrome.
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Why is it important?
The responses of insulin and HOMA-IR to ALE supplementation have shown an interaction with single-nucleotide polymorphism rs7903146 in TCF7L2, who are at increased risk of type 2 diabetes. Therefore, our findings suggest that patients with MetS and the TT genotype of TCF7L2-rs7903146 may most benefit from ALE consumption.
Perspectives
More studies are needed to clarify the efficacy of ALE as a complementary therapy for patients with MetS.
Khatereh Rezazadeh
Nutrition Research Center, School of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
Read the Original
This page is a summary of: TCF7L2-rs7903146 polymorphism modulates the effect of artichoke leaf extract supplementation on insulin resistance in metabolic syndrome: a randomized, double-blind, placebo-controlled trial, Journal of Integrative Medicine, June 2018, Elsevier,
DOI: 10.1016/j.joim.2018.05.006.
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