What is it about?
Twenty-seven treatment-naïve patients with relapsing-remitting multiple sclerosis (MS) and 13 with neuromyelitis optica spectrum disorder (NMOSD) were studied using flow cytometry in terms of cellular immunity in the blood as well as cerebrospinal fluid during a time of acute flare-up.
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Why is it important?
B cell activation in cerebrospinal fluid (CSF) is unique to acute MS relapse Acute flare-up in NMOSD is characterized by breakdown of the blood-brain barrier Intravenous corticosteroids have effects on cellular immunity in the CSF in MS Intravenous corticosteroids improve NMOSD by restoring the blood-brain barrier
Perspectives
Analysis of cerebrospinal fluid lymphocytes using flow cytometry is a useful means to investigate aberrant cellular immunity in neuroinflammatory disorders.
Professor Makoto Matsui
Kanazawa Medical University
Read the Original
This page is a summary of: Systemic cellular immunity and neuroinflammation during acute flare-up in multiple sclerosis and neuromyelitis optica spectrum disorder patients, Journal of Neuroimmunology, April 2021, Elsevier,
DOI: 10.1016/j.jneuroim.2021.577500.
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