What is it about?
Dimethyl sulfoxide (DMSO) is a widely used solvent for water-insoluble molecules and it has antioxidant, neuroprotective and cryopreservative effects. While DMSO is a regularly used solvent in research and a therapeutic agent, several cases of DMSO evoked seizures were reported in the literature. Therefore, we investigated the effect of different doses of DMSO on the absence-like epileptic activity of Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats.
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Why is it important?
We revealed that low doses of DMSO decreased whereas high doses of DMSO increased the absence-like epileptic activity of WAG/Rij rats.
Perspectives
As DMSO can modify the effects of the different antiepileptic drugs, particular care should be taken when evaluating the actions of these drugs administered in DMSO.
Dr Zsolt Kovacs
Eötvös Loránd University
Read the Original
This page is a summary of: The effect of intraperitoneally administered dimethyl sulfoxide on absence-like epileptic activity of freely moving WAG/Rij rats, Journal of Neuroscience Methods, April 2011, Elsevier,
DOI: 10.1016/j.jneumeth.2011.02.005.
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