What is it about?
Triazolopyrimidines are organic molecules biomimetic to the purine nucleobases present in DNA. We have synthesized copper (II) complexes based on these ligands and checked their antiparasitic activity against several leishmania and trypanosoma strains, who cause severes tropical illnesses.
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Why is it important?
Our experiments show a synergic effect in the copper complexes between the metallic centre and the triazolopyrimidine ligand, increasing the antiparasitic activity of these new drugs. Besides, the complexes present a moderate antiferromagnetic behaviour, what opens new potential applications for these compounds outside the biological field.
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This page is a summary of: In vitro leishmanicidal and trypanocidal evaluation and magnetic properties of 7-amino-1,2,4-triazolo[1,5- a ]pyrimidine Cu(II) complexes, Journal of Inorganic Biochemistry, March 2018, Elsevier,
DOI: 10.1016/j.jinorgbio.2017.11.027.
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