Steroid sulfatase regulated estrogen homeostasis inhibit inflammation

What is it about?

We uncover that the inflammatory activation of steroid sulfatase converts inactive estrogen sulfates to active estrogens in the liver, which in return attenuates inflammation via a negative feedback loop.

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Why is it important?

Chronic inflammatory liver diseases are associated with estrogen excess and feminization in men, which is thought to be due to compromised liver function to break down estrogens. We have shown for the first time that the inflammatory induction of steroid sulfatase (STS), which converts inactive estrogen sulfates to active estrogens, may have contributed to the estrogen excess in chronic liver disease.