What is it about?
A role for vitamin D supplementation in deficient/insufficient asthmatic children is controversial.
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Why is it important?
This is an accessory post hoc analysis from a larger vitamin D supplementation trial, analyzing results of the randomized stratum of older children receiving the high dose presenting with emergency department (ED) visits for asthma and baseline blood 25-hydroxyvitamin D concentration less than or equal to 25 ng/mL. Blinded randomization to clinic-administered IM 600,000 IU every 3 months + 400 IU orally daily at home or 400 IU orally daily at home (control group) was performed. The primary outcome was need for unplanned ED asthma exacerbation visit over 0 to 12 months for moderate to severe asthma.
Perspectives
We sought to compare high-dose intramuscular (IM) + daily oral maintenance vitamin D dose versus daily oral maintenance vitamin D dose for preventing asthma exacerbations in prospectively randomized vitamin D-deficient/insufficient children aged 5 to 14 years with moderate to severe asthma.
Dr Khalid Mohamed Alansari
Hamad Medical corporation
Read the Original
This page is a summary of: A randomized comparison of intramuscular high-dose versus oral maintenance vitamin D to prevent severe exacerbations in deficient/insufficient asthmatic children, Journal of Allergy and Clinical Immunology Global, August 2025, Elsevier,
DOI: 10.1016/j.jacig.2025.100497.
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