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Plasma activity of APP, a major metallopeptidase involved in kinin inactivation, is increased during androgen treatment. APP assay could be recommended as a predictive parameter of angioedema severity.
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This page is a summary of: Metallopeptidase activities in hereditary angioedema: Effect of androgen prophylaxis on plasma aminopeptidase P, Journal of Allergy and Clinical Immunology, February 2008, Elsevier,
DOI: 10.1016/j.jaci.2007.10.048.
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