What is it about?
High-throughput screening of Xenopus laevis egg extract identified NSC-95397 as a powerful inhibitor of DNA replication origin assembly. By targeting and destabilizing the CDC6 protein, NSC-95397 disrupts the loading of the MCM2-7 complex, leading to cell death in highly proliferative cancer cells, both in human models and Xenopus embryos.
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Why is it important?
This research highlights the potential of NSC-95397 as a targeted anti-cancer therapy that disrupts critical DNA replication processes.
Read the Original
This page is a summary of: A high-throughput screening identifies MCM chromatin loading inhibitors targeting cells with increased replication origins, iScience, August 2024, Elsevier,
DOI: 10.1016/j.isci.2024.110567.
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