What is it about?
Three types of levan were tested to see if they protect the stomach from ulcers. In rats, all three reduced ulcer size and number, with LevAE and LevZ working best. LevZ also boosted protective antioxidants and lowered harmful ones. The levans fought inflammation by blocking key chemicals like TNF-α and IL-1β. They were safe, improved cholesterol, and fed good gut bacteria. This suggests levan protects the stomach by calming inflammation through gut health.
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Why is it important?
Novelty lies in comparing three bacterial levans from honey isolates and linking their prebiotic activity directly to ulcer protection. This study is first to show that levan's gastroprotective effects work through prebiotic-mediated systemic immunomodulation reducing inflammatory markers like TNF-α, IL-1β, and NF-κB while boosting antioxidants. It establishes a clear correlation between gut health modulation and stomach ulcer healing.
Perspectives
This study reveals that levan's ulcer protection isn't just local it works through the gut, calming systemic inflammation. The clear correlation between prebiotic activity and ulcer healing is a fresh insight, suggesting we can treat stomach problems by nurturing beneficial bacteria. LevZ's strong antioxidant and anti-inflammatory profile makes it particularly promising. It's a shift toward holistic, microbiome-based therapy.
Gehan El-Bassyouni
National Research Centre (NRC), Dokki, Cairo, 12622, Egypt
Read the Original
This page is a summary of: Prebiotic-mediated gastroprotective potentials of three bacterial levans through NF-κB-modulation and upregulation of systemic IL-17A, International Journal of Biological Macromolecules, October 2023, Elsevier,
DOI: 10.1016/j.ijbiomac.2023.126278.
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